I haven't read much manga, but I know Fullmetal Alchemist, Yami no Matsuei, Saiyuki, and Weiss Kreuz, all of which feature at least one character who is blind in one eye. In the case of FMA, Yami, and Weiss, said characters are untrustworthy and often villainous. In the case of Saiyuki, the character is arguably a good guy, but he's done horrendous things in the past.
All of the characters lead double lives/are not quite human/should have died/went through some form of death at some point in the past. Two of them wear eyepatches. One of them has a prosthetic eye and wears glasses (which glint, which is a sign of a character not to be trusted in anime, at least, if not manga), and one of them wears a monocle over an eye that looks normal, but also might be prosthetic (it's never made clear).
I have no particular insight into Japanese culture, so it's possible I'm making connections where there are none, but blindness in one eye does often seem tied to a secret nature of some kind.
no subject
All of the characters lead double lives/are not quite human/should have died/went through some form of death at some point in the past. Two of them wear eyepatches. One of them has a prosthetic eye and wears glasses (which glint, which is a sign of a character not to be trusted in anime, at least, if not manga), and one of them wears a monocle over an eye that looks normal, but also might be prosthetic (it's never made clear).
I have no particular insight into Japanese culture, so it's possible I'm making connections where there are none, but blindness in one eye does often seem tied to a secret nature of some kind.